health care product nutrition supplement breviscapine with best price
product details
Product name:Erigeron breviscapus Extract
Extract source:Bergenia purpurascens.
Specification:98%
Active ingredient:Breviscapine
Used Part:flower
CAS NO. : 116122-36-2
Molecular formula :C21H18O12
Molecular weight:462.4
Appearance:light yellow Powder
Flavor: Characteristic taste
Particle Size:80% pass through 80 mesh sieve
Test mothed: HPLC
Extract Solvent: Ethanol & Water
Solubility: Soluble in water, ethanol
Usage: Pharmaceuticals, healthcares,and cosmetics
Product Description
Breviscapine is a mixture of flavonoid glycosides extracted from the Chinese herbs. Previous studies have shown that breviscapine possesses comprehensive pharmacological functions. However, very little is known about whether breviscapine have protective role on cardiac hypertrophy. The aim of the present study was to determine whether breviscapine attenuates cardiac hypertrophy induced by angiotensin II (Ang II) in cultured neonatal rat cardiac myocytes in vitro and pressure-overload-induced cardiac hypertrophy in mice in vivo. Our data demonstrated that breviscapine (2.5-15 microM) dose-dependently blocked cardiac hypertrophy induced by Ang II (1 microM) in vitro. The results further revealed that breviscapine (50 mg/kg/day) prevented cardiac hypertrophy induced by aortic banding as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting PKC-alpha-dependent ERK1/2 and PI3K/AKT signaling. Further studies showed that breviscapine inhibited inflammation by blocking NF-kappaB signaling, and attenuated fibrosis and collagen synthesis through abrogating Smad2/3 signaling. Therefore, these findings indicate that breviscapine, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of PKC-alpha-dependent signaling.
Product Analysis
| Item | Specification | Result | Method |
| BasicProduct Information |
| Product name | breviscapine | | |
| Part of the Plant | flower | Conform | / |
| Country of Origin | China | Conform | / |
| Organoleptic Data |
| Appearance | Fine powder | Conform | NLS-QCS-1008 |
| Color | Light yellow powder | Conform | GB/T 5492-2008 |
| Odor& Taste | Characteristic | Conform | GB/T 5492-2008 |
| Process Data |
| Solvent(s) Used | Water and ethyl alcohol | Conform | / |
| Extract ration | / | Conform | |
| Content | Paeoniflorin≥98% | 98.18 | |
| Drying Method | Spray drying | Conform | / |
| Excipient | Maltodextrin | Conform | / |
| Physical Characteristics |
| Particle Size (80 mesh) | 98.0%pass 80mesh | Conform | GB/T 5507-2008 |
| Moisture | <5.0% | 2.8% | GB/T 14769-1993 |
| Ash Content | <4.0% | 1.4% | AOAC 942.05, 18th |
| Solvent Residue | Eur. Pharm | Conform | NLS-QCS-1007 |
| Heavy Metals |
| Total Heavy Metals | <10 ppm | Conform | USP <231>, method II |
| Arsenic | <1.0 ppm | Conform | AOAC 986.15, 18th |
| Lead | <1.0 ppm | Conform | AOAC 986.15, 18th |
| Mercury | <0.5 ppm | Conform | AOAC 971.21, 18th |
| Pesticide Residue |
| 666 | <0.2ppm | Conform | GB/T5009.19-1996 |
| DDT | <0.2ppm | Conform | GB/T5009.19-1996 |
| Microbiology |
| Total Plate Count | <1,000cfu/g | 17cfu/g | AOAC 990.12, 18th |
| Total Yeast & Mold | <100cfu/g | 3cfu/g | FDA (BAM) Chapter 18, 8th Ed. |
| E. Coli | Negative | Negative | AOAC 997.11, 18th |
| Salmonella | Negative | Negative | FDA (BAM) Chapter 5, 8th Ed. |
Product Function
Pharmacological effects:
1, to improve cerebral blood circulation, increase cerebral blood flow, reducing vascular resistance, increase the permeability of the blood-brain barrier, conducive to the prevention and treatment of cerebral thrombosis formation.
2, the expansion of the coronary artery and peripheral vascular, reducing myocardial oxygen consumption, to increase nutrition myocardial blood flow, improve myocardial microcirculation.
3, lower cholesterol, reduce high blood viscosity, platelet aggregation.
4, increasing the phagocytic function of the liver reticuloendothelial cells and macrophages, increased blood CAMP content, improve the immune system.
5, inhibition of intravascular coagulation, fibrinolysis promoting, reducing fibrinogen, and anti-tied thrombolysis.
Functions and Indications:
The blood stasis Tongluozhitong. Suitable for hemiplegia, cerebral infarction, cerebral thrombus formation, sequelae of stroke, coronary heart disease, angina, ischemic heart disease, Alzheimer's the hyperviscosity, dizziness psychosis.
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